Why does penicillin G benzathine have to be given IM?

Penicillin G benzathine and penicillin G procaine injection should never be given intravenously (into a vein), because this may cause serious or life-threatening side effects or death.

Why is penicillin given intramuscularly?

Penicillin G benzathine intramuscular injections are primarily used to treat Treponema infections and to eradicate colonization of group A β-hemolytic streptococci in chronic carriers. Benzathine is the least soluble salt form of penicillin G, thus providing the longest duration of action (up to 3 weeks).

How is penicillin G benzathine administered? Penicillin G benzathine must be injected slowly and deeply into a muscle of the buttock or hip. Do not inject this medicine near or into an artery, vein, or nerve. Dangerous or fatal side effects could occur. Prepare an injection only when you are ready to give it.

Why is penicillin G benzathine not given IV?

Penicillin G benzathine injection should never be given intravenously (into a vein) because this may cause serious or life-threatening side effects or death.

Is penicillin G IV or IM?

The IDSA states that penicillin is the treatment of choice for erysipelas. 200,000 to 300,000 units/kg/day IV or IM in divided doses every 4 to 6 hours (Max: 24 million units/day) is recommended by the American Academy of Pediatrics (AAP) for severe infections.

How quickly does penicillin shot work?

Penicillin shot can clear infection in 8 hours, but its painful and expensive.

Is penicillin injection painful?

Intramuscular (IM) Penicillin G Benzathine (PGB) is the cornerstone of the treatment of primary syphilis [1], but its administration is associated with sharp pain at the site of the injection that sometimes may be of severe intensity.

How long does it take to cure syphilis after penicillin shot?

Antibiotics for syphilis Syphilis that has lasted less than 2 years is usually treated with an injection of penicillin into your buttocks, or a 10-14 day course of antibiotic tablets if you can’t have penicillin.

How long does penicillin G benzathine stay in your system?

Due to the slow absorption and the hydrolysis, the concentration of the drug in the blood remain lower but for a prolonged period of time. After a 1.2 million unit injection, adults have detectable drug concentrations for 14 days, often longer. The medication is excreted by renal tubular excretion.

What are the side effects of a penicillin shot?

Get medical help right away if you have any very serious side effects, including: pain/redness/swelling/numbness/weakness of arms/legs, change in skin color near the injection site or on arms/legs, severe pain/peeling skin at the injection site, muscle cramps/weakness around the injection site, inability to move ( …

How do you mix a benzathine penicillin shot?

Reconstitution of the suspension for intramuscular injection: The suspension must be prepared aseptically. The contents of the vial should be reconstituted in at least 2ml (0.6 Million I.U.), 3.5ml (1.2 Million I.U.), or 5ml (2.4 Million I.U.) of diluent (e.g. water for injections which is included in the pack).

What is penicillin G benzathine used for?

What is penicillin G benzathine and penicillin G procaine? Penicillin G benzathine and penicillin G procaine is a combination slow-onset antibiotic that is used to treat many types of severe infections caused by bacteria, including strep infections, pneumonia, and scarlet fever.

How do you give a penicillin shot to a human?

Penicillin G procaine (aqueous) is for intramuscular injection only. Administer by DEEP INTRAMUSCULAR INJECTION in the upper, outer quadrant of the buttock. In neonates, infants and small children, the midlateral aspect of the thigh may be preferable. When doses are repeated, vary the injection site.

Can penicillin G be given IM?

Bicillin L-A (penicillin G benzathine injectable suspension) is available for deep intramuscular injection.

Do penicillin shots cure STDS?

There are no home remedies or over-the-counter drugs that will cure syphilis, but syphilis is easy to cure in its early stages. A single intramuscular injection of long acting Benzathine penicillin G (2.4 million units administered intramuscularly) will cure a person who has primary, secondary or early latent syphilis.

Where do you inject penicillin?

Penicillin G injection is usually injected into a muscle or vein but may also be given directly into the lining of the chest cavity, into the fluid surrounding the spinal cord, or into a joint or other areas.

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